|Biocatalysis to cosmetic active ingredients|
|Enzymes as actives|
Synthesis of a cosmetic ingredient using a biocatalyst catalyzing the transesterification reaction. Three parameters had to be improved: selectivity towards the targeted alcohol group (3 possibilities !), selectivity towards an impurity which is present in the substrate and very similar to the substrate ester and rate of conversion.
Using EvosightTM, enzymes improved for each parameter were obtained.
- Selectivity towards the targeted alcohol group: 95% vs 85%
- Selectivity towards the impurity: 1% vs 3%
- Rate of conversion: gain of 20%
Increase aqueous solubility of active ingredients: glycosyl transferases
Highly selective enzymes – Broad natural substrates scope:
Advantages of the biocatalytic process:
- Regio- and enantioselectivity
- No protecting group
- High substrate loading
Increase of aqueous solubility (Catalysts 2018, 8, 387; doi:10.3390/catal8090387)
Screening of microalgae strains for high value ingredients
Abacus is a 3-year project aiming at a business-oriented and technology-driven development of a new algal biorefinery, thereby bringing to the market innovative algae-based ingredients for high value applications, with focus on algal terpenes for fragances to long-chain terpenoids (carotenoids) for nutraceuticals and cosmetic actives.