Directed evolution for improved transgene expression in GM crops

Improve activity of transgenes by directed evolution:

  • Adapt microbial genes for optimal expression and activity in a plant system
  • Change toxins specificity for insect control
  • Insertion of new synthesis pathways to increase nutritional value of plants: production of vitamins, unsaturated fatty acids or omega 3 fatty acids.

Optimization of synthesis of chiral and complex agrochemicals


Rising demand for complex and chiral molecules agrochemicals
due to:

  • Development of chiral molecules in order to increase activity and reduce toxicity (example: R-napropamide vs S-napropamide)
  • Development of bioinspired molecules, such as pheromones, which are complex chiral molecules

Proteus can develop biocatalytic pathways to optimize production
processes for chiral molecules:

  • enzymatic resolution of a racemic product
  • development of a new pathway for chiral synthesis
  • generate Intellectual Property on alternative pathways

Development of new products for biocontrol and biostimulants

Biopesticides: DIETETIC project

  • The goal of the project is to identify protein toxins exhibiting insecticide activities against the corn rootworm (Diabrotica virgifera virgifera).
Diabrotica virgifera virgifera
  • 1300 strains of Proteus collection were sequenced and screened for insecticide activities against the larva of the corn rootworm.
  • Patent pending on novel protein toxins
  • Proteus is looking for industrial partners

Biofungicides: FONGIZYME project

The goal of the project is to identify enzymatic cocktails exhibiting fungicide activities against Botrytis cinerea

Grapevine infected by Bortyris cinerea
Grapevine infected by Bortyris cinerea
  • Mode of action: hydrolysis of the fungi cell wall
  • Supported enzymes used in order to increase stability

Biostimulants / biofertilisers

  • Isolation of new strain from soils, roots
  • Characterization of strains